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与甘油三相关的指数和急性胰腺炎的风险:英国生物银行的一项前性研究
Jing-Bo Li1, Yu-Jiao Zhu1, Yang-Jie Liao2
1Department of Gastroenterology, the Third Xiangya Hospital, Central South University, Changsha, China.
与甘油三相关的指数升高,如甘油三-葡萄糖 (TyG) 和TyG-WHtR,与急性胰腺炎 (AP) 的更高风险有关. 泰格-WHtR指数显示了AP发作的最强的预测能力.
科学领域:
- 代谢健康和胰腺疾病
- 生物标志物发现发现
- 评估心血管风险评估
背景情况:
- 与甘油三相关的指数 (例如,甘油三-葡萄糖 (TyG)) 是已确定的胰岛素抵抗的标志物.
- 这些指数与急性胰腺炎 (AP) 风险之间的关联仍未得到充分研究.
- 了解这些联系可以帮助早期识别AP风险.
研究的目的:
- 调查各种与甘油三相关的指数与患急性胰腺炎 (AP) 的风险之间的关联.
- 确定哪个与甘油三相关的指数,如果有的话,是AP最强的预测指标.
- 探索这些指标的剂量反应关系和预测性能AP.
主要方法:
- 利用了英国生物银行387275名参与者的数据.
- 采用考克斯回归模型来评估与甘油三相关的指数与AP风险之间的关联.
- 应用受限立方线 (RCS) 和接收器运行特征 (ROC) 曲线用于关系分析和可视化.
主要成果:
- 所有测试的与甘油三相关的指数 (TyG,AIP,TyG-BMI,TyG-WC,TyG-WHtR,CMI,VAI,LAP) 都与AP的风险增加显著相关.
- 大多数指数的最高四分位数显示,与最低四分位数相比,AP的危险比率大幅增加.
- 泰格-WHtR指数显示了最强的预测能力AP发作,与大多数指数观察到的非线性关系.
结论:
- 与甘油三相关的指数升高与急性胰腺炎的风险增加有关.
- 甘油三糖与腰与身高的比率 (TyG-WHtR) 指数成为识别早期AP风险个体的强有力的预测指标.
- 这些发现表明TyG-WHtR可能是AP风险分层的有价值的临床工具.
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