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Updated: Mar 11, 2026

Vibratome Sectioning Mouse Retina to Prepare Photoreceptor Cultures
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Vibratome Sectioning Mouse Retina to Prepare Photoreceptor Cultures

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与棒 Dystrophy 相关的 WDR34 对于乳腺完整性和哺乳动物光受体细胞的生存至关重要

Rong Zou1,2, Jinrui Cai1, Lin Fan1

  • 1The Sichuan Provincial Key Laboratory for Genetic Diseases, Center for Medical Genetics, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

Investigative ophthalmology & visual science
|March 10, 2026
PubMed
概括

在小鼠中,WDR34缺乏导致光受体退化,影响视力. 基因疗法在保护光受体功能和结构方面显示出前景,为视网膜疾病治疗提供了希望.

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Photoreceptors and Visual Pathways

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Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
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In humans, the photoreceptor cells of the eye and sensory hair cells of the ear lack stem cells. These cells are thus unrenewable and cannot be replaced when they are damaged or destroyed.
Photoreceptors
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