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Updated: Mar 11, 2026

Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity
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切利尼布通过向DRP-1诱导甲状腺癌细胞中的线粒体分裂

Dongguang Qin1, Wei Ding1, Xuesong Wu1

  • 1Department of Head and Neck Surgery, Shanxi Province Cancer Hospital, Taiyuan, Shanxi, China.

Drug development research
|March 10, 2026
PubMed
概括

切利尼布通过激活 mitochondrial Calcium Uniporter (MCU) /calpain 途径来破坏甲状腺癌细胞中的线粒体动力学,从而导致细胞功能障碍. 这揭示了切利尼尼在治疗甲状腺癌中的新治疗机制.

关键词:
在DRP-1中,它是DRP-1的.切利尼尼布 (ceritinib) 是一种线粒体功能 线粒体功能甲状腺癌细胞癌

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