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冠状管新血管化的新型定量OCTA生物标志物和与疾病活动和病因学的关联

Yuhong Gan¹, Jiaxin Pu¹, Shishi Yang¹

¹State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, People's Republic of China.

Translational vision science & technology

|March 10, 2026

概括

一个新的半自动光学连贯性断层扫描血管学 (OCTA) 框架量化胆道新血管化 (CNV) 形态. 该工具准确地区分了CNV类型和活动,有助于临床评估和个性化治疗策略.

科学领域:

眼科医生眼科眼科
医疗成像医学成像
生物医学工程生物医学工程

背景情况:

胸腔新血管化 (CNV) 呈现出不同的病因和形态模式.
准确评估CNV活动和形态,对于有效的治疗规划至关重要.
目前用于CNV评估的方法可能缺乏客观性和标准化.

研究的目的:

开发一个半自动化的光学连贯性断层扫描血管学 (OCTA) 框架,用于对CNV进行定量形态评估.
调查量化OCTA指标与CNV病因,活性和病变模式之间的关联.
为CNV评估和管理建立一个客观,非侵入性的工具.

主要方法:

对新血管与年龄相关的黄斑变性 (nAMD),近视性CNV (mCNV) 或炎症性CNV (iCNV) 的治疗先眼睛的回顾性分析.
使用集成AngioTool,ImageJ和自定义Python算法的标准化管道处理的OCTA图像.
提取血管网络和轮异质度指标用于定量分析.

主要成果:

在nAMD,mCNV和iCNV组中观察到病变形态 (大小,分支,血管面积,周长,MaxFeret,MinFeret,血管总长) 的显著差异.
iCNV病变显示出明显的轮不规则性,圆形度最低,陷深度最高.
一个五参数模型准确地区分了活跃与非活跃的CNV (AUC = 0.901).

结论:

定量性OCTA生物标志物有效地区分CNV病因和活动.
开发的框架为CNV的临床评估提供了一个非侵入性,客观的基础.
这种方法促进了个性化治疗规划,并优化了疾病监测.

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