在2型糖尿病中补充维生素D:随机对照试验的系统审查
Dimitrios Papandreou1, Salwa Bader2, Khaled Abass3,4
1Department of Clinical Nutrition and Dietetics, CHS, University of Sharjah, Sharjah, UAE.
Journal of dietary supplements
|March 10, 2026
概括
补充维生素D可以改善2型糖尿病患者的血糖控制. 然而,它并不总是有利于其他代谢标记物. 建议根据个体维生素D水平进行有针对性的补充.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 营养科学 营养科学
背景情况:
- 维生素D缺乏是常见的2型糖尿病 (T2DM).
- 维生素D补充剂对T2DM代谢控制的影响仍在争论中.
- 现有的研究表明,关于维生素D的有效性,结果各不相同.
研究的目的:
- 系统地审查维生素D补充剂对T2DM或糖尿病前期成人血糖控制和代谢参数的影响.
- 评估主要结果:HbA1c,禁食血糖 (FBG) 和HOMA-IR.
- 为了评估二次结果:脂质概况,血压和人体测量.
主要方法:
- 随机对照试验 (RCT) 的系统审查和叙述合成,遵循柯克伦和PRISMA的指导方针.
- 在PubMed,Scopus和Web of Science进行的搜索截至2025年3月.
- 使用Cochrane RoB 2工具重复数据提取和偏差风险评估.
主要成果:
- 包括30个RCT (n=2627),使用不同的维生素D剂量和持续时间.
- 补充剂持续增加了血清25(OH) D水平.
- 大约一半的研究显示HbA1c和FBG的减少,特别是在维生素D缺乏的人群中. HOMA-IR效应是混合的. 二次结果显示最小的变化.
结论:
- 维生素D补充剂可以提高T2DM患者的血糖控制与同时缺乏.
- 对于具有足够维生素D水平的人来说,补充似乎无效.
- 建议基于个体状况的向维生素D补充剂,而不是普遍的管理.
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