延迟发作的卡里普拉诱导的阿卡西西亚:一个病例报告
Zachary Goodrich1, Drew Grehan2
1Macon and Joan Brock Virginia Health Sciences Eastern Virginia Medical School at Old Dominion University, Norfolk, VA.
Clinical neuropharmacology
|March 10, 2026
概括
延迟发病的阿卡西西亚是卡里普拉的罕见副作用,可以模仿焦虑. 本案例报告强调考虑超出典型的4周窗口的阿卡西西亚,特别是加里普拉抗精神病治疗.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 临床案例研究 临床案例研究
背景情况:
- 阿卡西西亚是抗精神病药物的常见额外皮拉米德副作用.
- 从原发性焦虑症中区分阿卡西西亚可能是具有挑战性的.
- 卡里普拉辛是一种非典型的抗精神病药物,用于治疗双相情感障碍和精神分裂症.
研究的目的:
- 报告卡里普拉辛诱导的延迟发病的阿卡西西亚病例.
- 讨论潜在的药理动力学和药理动力学机制.
- 为了突出诊断挑战和加利普拉诱导的阿卡西西亚的延长时间表.
主要方法:
- 病人的病史和精神病史的回顾性审查.
- 关于抗精神病药物诱导的阿卡西西亚的综合文献综述.
- 一个患有双相情感障碍和泛性焦虑障碍的患者的案例介绍.
主要成果:
- 一名42岁的女性在开始服用卡里普拉10周后出现了严重的焦虑和失眠.
- 症状最初被错误地归因于焦虑.
- 抗精神病药物诱导的阿卡西西亚的诊断在精神病学咨询后得到证实.
- 迪芬胺的使用导致了症状的快速改善.
- 停用卡里普拉导致持续的症状消失.
结论:
- 延迟发作的阿卡西西亚是一种临床上未被认可的cariprazine的表现.
- 应考虑超出典型的4周发病期,特别是与cariprazine.
- 卡里普拉辛独特的药理动力学和药理动力学特性可能有助于延迟阿卡西西亚的发生.
相关概念视频
01:24Parkinson's Disease: Treatment
1.3K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.3K
01:28Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
706
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
706
01:08Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
320
Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
320
01:20Antiepileptic Drugs: Potassium Channel Activators
880
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
Ezogabine has gained approval as an adjunctive treatment...
880
01:27Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
758
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
758
01:29Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
1.0K
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
Phenothiazines, such as prochlorperazine...
1.0K