脊柱脂肪组织,冠状动脉斑块进展和主要不良心血管事件:一个多中心研究
Annalisa Filtz1, Daniel Lorenzatti1, Andrea Scotti1
1Cardiology Division, Montefiore Health System/Albert Einstein College of Medicine, Bronx, New York, USA.
JACC. Cardiovascular imaging
|March 10, 2026
概括
高心上脂肪组织 (EAT) 容量与冠状动脉疾病 (CAD) 的存在和进展有关. 这一发现突出了EAT作为风险分层的潜在标志物和早期,更密集的治疗的目标.
科学领域:
- 心脏病学 心脏病学
- 放射学 放射学是一门学科.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 心脂肪组织 (EAT) 与冠状动脉疾病 (CAD) 有关.
- EAT和斑块进展 (PP) 之间的关系,这是主要不良心血管事件 (MACE) 的预测因素,尚未完全理解.
研究的目的:
- 为了研究EAT体积 (EATv) 和CAD之间的关联.
- 检查EATv,斑块进展 (PP) 和随后的MACE之间的关系.
主要方法:
- 利用了来自PARADIGM注册表的数据,包括串行冠状动脉计算机断层扫描血管图.
- 评估斑块体积 (PV),动脉瘤体积百分比 (PAV) 和PP,将快速斑块进展 (RPP) 定义为每年PAV增加≥1%.
- 测量EAT体积 (EATv) 和高级斑块特征,进行多变量分析以评估MACE的关联和预后值.
主要成果:
- 患有CAD的患者的EATv明显高于没有的患者.
- 较高的EATv tertiles与斑块体积和成分的更大进展有关.
- PP和RPP的患病率在EATv三级动物中增加,高EATv与斑块存在,PP和RPP独立相关.
- PP和RPP与较低的10年无MACE生存率有关.
结论:
- 升高的EAT体积独立地与CAD的存在和进展有关.
- EATv显示出作为心血管风险分层的生物标志物的潜力.
- 向EAT可能为早期或更密集的CAD治疗提供策略.
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