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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
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通过ROS介导的分子激活利用X射线诱导的NIR-II余光,用于瘤放射性疗法.

Jining Qin1, Binlong Zhang1, Kang Zhu1

  • 1State Key Laboratory of Chemical Resource Engineering, College of Chemistry, College of Chemical Engineering, Beijing University of Chemical Technology, Beijing 100029, China.

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概括

我们开发了一种新的X射线激活有机后发光探针,用于深层组织成像和癌症治疗. 这个探针在NIR-II窗口中发射,通过减少辐射剂量来增强瘤细胞根除.

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科学领域:

  • 生物医学工程 生物医学工程
  • 材料科学 材料科学 材料科学
  • 在瘤学瘤学.

背景情况:

  • 由X射线激活的有机后照探针显示出深层组织成像和癌症治疗的前景.
  • 目前的限制包括短波长的辐射和低效的反应性氧物种 (ROS) 的产生.

研究的目的:

  • 开发一种分子工程小分子探针,用于深层组织成像和癌症治疗,使用X射线触发后发光 (AGL) 在第二近红外 (NIR-II) 窗口中.
  • 为了克服传统X射线响应剂的局限性.

主要方法:

  • 设计了一种结合的捐赠者-π-接受器 (D-π-A) 小分子探针,配有氧-阿达曼提利丁捐赠器和罗达胺酸盐接受器.
  • 利用扩展的π-结合和减少的兴奋状态能量,以实现高效的NIR-II发射 (高达~1100 nm).
  • 研究了X射线诱导的单点氧生成和NIR-II后光生成的化学激发.

主要成果:

  • 在X射线照射后实现了高效的NIR-II后发光.
  • 证明了持续的单点氧生产,增强了瘤细胞的根除.
  • 展示了治疗效果所需的减少辐射剂量.

结论:

  • 开发了一个统一的平台,用于NIR-II光照导向后辐射.
  • 理性分子工程可以克服传统X射线响应剂的局限性.
  • 实现了空间时间控制的癌症诊断和治疗.