强迫症和抑郁症的深度大脑刺激:从神经电路到个性化神经调节
Joel Zen-Yew Chiu1, Yeannie Hui-Yeng Yap1, Soon-Hao Tan2
1Division of Applied Biomedical Sciences and Biotechnology, School of Health Sciences, IMU University, Kuala Lumpur, Federal Territory of Kuala Lumpur, Malaysia.
International journal of psychiatry in medicine
|March 10, 2026
概括
深度大脑刺激 (DBS) 对严重强迫症 (OCD) 和治疗耐药性抑郁症 (TRD) 的治疗有希望. 虽然对强迫症有效,但TRD的结果是混合的,需要进一步研究个性化神经调节策略.
科学领域:
- 神经学 神经学
- 精神病学是一个精神病学.
- 神经外科 神经外科
背景情况:
- 深度大脑刺激 (DBS) 是对强迫症和TRD等严重,耐治疗的精神疾病的潜在治疗方法.
- 传统疗法对于这些疾病往往是无效的.
研究的目的:
- 本综述综合了当前的证据和DBS在严重,耐治疗精神疾病的进展.
- 它检查了强迫症和TRD的不同临床轨迹和挑战.
主要方法:
- 在PubMed和谷歌学者 (2020-2025) 中进行了全面的文献搜索.
- 关键词包括"DBS"",深度大脑刺激"",强迫症"",TRD"",耐治疗抑郁症"和"精神病神经调节".
主要成果:
- DBS在强迫症治疗中显示了持续的长期益处,尽管最近的试验显示效果大小较小.
- TRD结果不一致; 开放试验显示高响应率,但随机试验没有显著优于假刺激.
- 创新包括连接的目标定位,AI预测模型和闭环DBS系统.
结论:
- DBS仍然是对耐火性强迫症和TRD的有前途的治疗方法.
- 未来的进步需要解决方法学,伦理和翻译方面的挑战.
- 个性化,数据驱动的神经调制策略对于进步至关重要.
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