多种起源和功能:病毒中HSP70蛋白的进化途径
Ayoub Maachi1, Santiago F Elena2,3
1Regional Center for Agronomic Research of Agadir, National Institute for Agronomic Research (INRA), Inezgane, 86350, Agadir, Morocco.
The Journal of general virology
|March 10, 2026
概括
热冲击蛋白70s (HSP70s) 在各种病毒中发现,包括具有dSDNA基因组的病毒. 它们的存在表明多个独立的基因获取和病毒蛋白质组中的多种进化路径.
科学领域:
- 病毒学 病毒学
- 分子生物学分子生物学
- 进化生物学 进化生物学
背景情况:
- 热冲击蛋白70s (HSP70s) 是关键的分子陪伴者,参与所有生命领域的细胞应激反应.
- 以前的研究在ssRNA病毒 (closteroviruses) 中发现了HSP70同类物,但它们的更广泛的病毒分布和演变尚不清楚.
研究的目的:
- 为了全面搜索病毒蛋白数据库的HSP70同类超出ssRNA病毒.
- 研究病毒HSP70s的进化史,基因组织和结构多样性.
主要方法:
- 病毒蛋白数据库的生物信息搜索.
- 对已识别的HSP70序列进行结构和遗传学分析.
- 从dDNA和ssRNA病毒中对HSP70s进行比较分析.
主要成果:
- 在具有dSDNA基因组的病毒 (Megaviricetes类) 中,与ssRNA病毒一起,发现了HSP70同类物.
- 病毒HSP70s表现出多样化的基因组织,副本数量 (在Megaviricetes中高达三种) 和结构特征.
- 遗传学分析揭示了两个主要集群:类似宿主原生体的dsDNA病毒HSP70s和独特的ssRNA病毒HSP70s.
结论:
- 多个独立的横向基因转移事件可能导致病毒获得HSP70基因.
- 病毒HSP70s表现出不同的进化轨迹,其中*Megaviricetes*HSP70s可能是从宿主中获得的,而closterovirusHSP70s正在迅速进化.
- 这些发现为病毒进化和分子伴侣的功能适应提供了新的见解.
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