在严重炎症性肠病中表皮SLPI表达与高IL-17和中性粒细胞编程有关
Sandrine Nugteren1, Beatriz Calado1, Ytje Simons-Oosterhuis1
1Gastroenterology and Nutrition, Erasmus University Medical Center, Rotterdam, Netherlands.
JCI insight
|March 10, 2026
概括
结肠中的分泌白细胞蛋白酶抑制剂 (SLPI) 与严重的儿科炎症性肠病 (IBD) 有关. 高的SLPI表明炎症增加,并表明IBD患者的潜在治疗耐药性.
科学领域:
- 胃肠道学和免疫学
- 微生物组与宿主之间的相互作用
背景情况:
- 炎症性肠病 (IBD) 在严重程度和治疗反应方面表现出显著的异质性.
- 目前的组织学评估缺乏参数来定义IBD中的特定免疫机制.
- 了解宿主 - 微生物群 - 免疫相互作用对于IBD病原发生至关重要.
研究的目的:
- 为了确定在未经治疗的儿科IBD患者中区分免疫特征的组织学特征.
- 调查分泌白细胞蛋白酶抑制剂 (SLPI) 在IBD免疫病理学中的作用.
主要方法:
- 在两个儿科IBD队列中分析了活检免疫组织化学,转录组学和血蛋白学.
- 结肠表皮SLPI表达与临床,内镜和显微镜疾病活动的相关性.
- 评估免疫细胞透 (中性粒细胞,IL-17分泌细胞) 和血蛋白度.
主要成果:
- 高结肠SLPI表达与IBD的临床,内镜和显微镜疾病严重程度增加相关.
- 升高的SLPI与增加的中性粒细胞透,Th17通路激活和治疗耐药性特征有关.
- 患有高SLPI的患者表现出明显的循环中性粒细胞转录形状,影响免疫信号和功能.
结论:
- 在诊断时高结肠SLPI是重症儿科IBD的标志物.
- SLPI表达与增加的IL-17A中性粒细胞反应和改变的中性粒细胞免疫型有关.
- SLPI可能代表IBD分层的新型治疗标或生物标志物.
相关概念视频
01:30Inflammatory Bowel Disease II: Crohn's Disease
1.4K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.4K
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
1.3K
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
1.3K
01:17Chronic Bowel Disorders: Introduction
868
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
868
01:23Renewal of Intestinal Stem Cells
3.5K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
3.5K
01:27Histology of the Small Intestine
4.4K
The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
4.4K
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
994
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
994