宿主耐药性和病原体利用在传播剂介导的感染模型中的共同进化
Prerna Singh1,2, Justin Sheen2,3, Chadi M Saad-Roy4,5,6,7,8
1Evolutionary and Integrative Ecology, Leibniz Institute of Freshwater Ecology and Inland Fisheries, Berlin, Germany.
PLoS computational biology
|March 10, 2026
概括
宿主耐药性以最大限度地提高病原体的传播,而高成本的耐药性则在中间感染水平上受到青. 同进化可以抑制或放大病原体的流行,这取决于传播动态.
科学领域:
- 进化生物学是进化的生物学.
- 流行病学 流行病学
- 人口动态 人口动态
背景情况:
- 在环境中持续存在的病原体对宿主群体构成感染风险.
- 环境传播依赖于自由生存的病原体传播.
- 了解宿主-病原体共同进化对于疾病生态学至关重要.
研究的目的:
- 模拟宿主抵抗环境传播病原体的进化.
- 分析宿主耐药性和病原体利用策略之间的共同进化动态.
- 预测这些共同进化反如何影响病原体流行.
主要方法:
- 使用适应动态框架开发了人口层面的模型.
- 计算宿主和病原体入侵适应性表达式.
- 分析了基于生存的健身成本下的进化稳定策略和进化分支.
主要成果:
- 昂贵的宿主耐药性被选择用于非常高的病原体遭遇率.
- 最大宿主电阻在中间传输水平上演变.
- 同进化反可以导致稳定的策略或进化分支,产生特征多样性.
- 同进化可以抑制或放大平衡病原体的传播密度.
结论:
- 主体抵抗的演变取决于传输速率和相关的健康成本.
- 主体和环境传播的病原体之间的共同进化动态为耐药性水平和病原体流行率带来了复杂的结果.
- 该模型为宿主-病原体系统提供可测试的预测,其中包括环境传播和基于生存的成本.
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