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松素或尼古丁贴片用于戒烟:试点随机临床试验

Matthew W Johnson¹, Gideon P Naudé¹, Peter S Hendricks²

¹Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.

JAMA network open

|March 10, 2026

概括

在试点试验中,与尼古丁贴片加CBT相比,与认知行为疗法 (CBT) 结合的psilocybin表现出明显更高的长期戒烟率. 这表明psilocybin可能是一个有前途的新疗法,用于烟草戒烟.

科学领域:

精神病学是一个精神病学.
临床心理学临床心理学
药理学药理学是指药理学的学科.

背景情况:

在全球范围内,吸烟仍然是可预防死亡的主要原因.
现有的戒烟干预措施,如尼古丁替代疗法和认知行为疗法 (CBT),提供适度的长期成功率.
需要新的治疗方法来改善戒烟的结果.

研究的目的:

为了比较西与CBT结合的疗效与尼古丁贴片加CBT在实现长期戒烟方面.
评估psilocybin作为戒烟辅助剂的安全性和可行性.

主要方法:

一项试点随机临床试验与精神健康的成年吸烟者进行.
参与者被随机分配,接受单次高剂量的西或8-10周的尼古丁贴片治疗.
两组都接受了为期13周的手动CBT计划,以戒烟.
主要结局是在戒烟日期后6个月内经过生物化学验证的长期戒烟.

主要成果:

在6个月的随访中,接受psilocybin的参与者中有40.5%实现了长时间的戒断,而接受尼古丁贴片的参与者中有10.0% (OR=6.12,P=.003).
西也显示了更高的7天禁酒点流行率 (52.4%对25.0%,OR=3.30,P=.01).
没有严重的不良事件归因于psilocybin或尼古丁贴片.

结论:

与尼古丁贴片加CBT相比,单剂量psilocybin与CBT相结合显著提高了长期戒烟率.
这些发现表明,psilocybin作为一种新且有效的烟草戒烟药物疗法具有前景.
需要进一步的研究,以在更大的试验中证实这些结果.

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