6-n-propylthiouracil味道表型与固定牙科治疗期间初始病变的发展之间的关联:一项前性队列研究
Ulaganathan Sangeetha1, Balasubramanian Madhan2, Shivangi Ramteke1
1Division of Orthodontics and Dentofacial Orthopedics, Department of Dentistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
概括
具有6-n-propylthiouracil (PROP) 非品尝者表型的人在正牙治疗期间患初始病变 (ICL) 的风险明显更高. 这种味觉表型可能会影响的发病率和严重程度.
科学领域:
- 口腔健康研究 口腔健康研究
- 牙损流行病学 牙损流行病学
- 遗传学和味觉感知的遗传学
背景情况:
- 固定牙科治疗对保持口腔卫生提出了独特的挑战.
- 初始病变 (ICL) 的发展是正义牙科治疗期间的常见并发症.
- 味觉的个体差异,如6-n-propylthiouracil (PROP) 苦味表型,可能会影响口腔健康行为和结果.
研究的目的:
- 研究6-n-propylthiouracil (PROP) 味道表型与初始病变 (ICL) 的发生率和严重程度之间的关联.
- 探索味觉在固定牙科治疗期间牙损伤的发展中的作用.
主要方法:
- 一项前性队列研究,涉及44名接受固定牙科治疗的患者.
- 参与者根据他们的苦味感知被分为PROP非品尝者或品尝者.
- 测量结果包括12个月内ICL的累积发病率 (Cin) 和严重程度 (Enamel脱指数,EDI),并对潜在的混因素进行了调整.
主要成果:
- 与9个月 (RR=13.4) 和1年 (RR=2.5) 的品尝者相比,非品尝者表现出明显更高的发展ICL的相对风险 (RR).
- 一般化的线性模型表明,在非品尝者中,ICL发展的几率更高 (OR=2.8).
- 虽然EDI得分在非品尝者中略高,但病严重程度的差异在临床上并不显著.
结论:
- 这些发现表明,一个人的味觉表型,特别是PROP非品味者身份,可能在固定牙治疗期间在初始病变的发展中发挥作用.
- 味觉感知可能是影响牙损伤风险的一个因素,在接受正牙护理的患者中.
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