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器官在芯片上的设备模拟牙-真菌复合物:质量系统性审查

Josefa Baeza-Fernández1, Cristina Bucchi2,3

  • 1Master Program in Dentistry, Faculty of Dentistry, Universidad de La Frontera, Temuco, Chile.

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在体外 (in vitro) 技术.牙 - 纸接口接口牙周内学 牙周内学微流体装置是一种微流体装置.在芯片上的牙

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科学领域:

  • 生物材料工程 生物材料工程
  • 翻译牙科 翻译牙科
  • 微流体在再生医学中的作用

背景情况:

  • 微流体设备为模拟生物环境提供了有希望的平台.
  • 牙-肉复合物由于其复杂的结构和细胞组成,为体外建模带来了独特的挑战.

研究的目的:

  • 系统地审查开发和应用模仿牙-肉复合体的微流体设备.
  • 为了确定当前的趋势,局限性和未来的方向在这个研究领域.

主要方法:

  • 在主要的电子数据库中进行了系统的文献搜索.
  • 包含了以微流体设备为牙-肉接口的体外研究.
  • 用QUIN工具进行偏差评估,分析了设备设计,制造,接口特性,培养方法,结果和测量技术.

主要成果:

  • 五项研究符合纳入标准,显示了设备设计,制造和通道特征的显著变化.
  • 大多数研究都采用静态培养条件,只有一个研究采用动态流体流.
  • 测量的主要结果包括细胞活力,口腔细胞形态和代谢活性.

结论:

  • 目前关于牙 - 纸复合体微流体模型的研究是有限的,并且在制造,设计和材料方面表现出相当大的异质性.
  • 尽管已知动态流动的好处,但静态培养的占主导地位阻碍了生理学上准确的模型的开发.
  • 未来的研究需要集成动态流系统和全面的报告标准,以提高可复制性,并为牙科研究创建更相关的体外模型.