欧洲使用抗抑郁药物:过去的使用情况,处方模式和到2030年的预测
Lilly Josephine Bindel1, Roland Seifert2
1Institute of Pharmacology, Hannover Medical School, 30625, Hannover, Germany.
International journal of clinical pharmacy
|March 10, 2026
概括
抗抑郁药的使用在欧洲正在增加,选择性色素再吸收抑制剂 (SSRI) 占据了处方的主导地位. 未来的趋势预测持续增加,尽管观察到区域差异和药物类别的变化.
科学领域:
- 药监和药物利用研究 药监和药物利用研究
- 公共卫生和流行病学
- 心理药理学 心理药理学
背景情况:
- 精神疾病,特别是抑郁症,对全球的健康造成了重大负担.
- 抗抑郁药 (ADs) 是治疗精神健康状况的主要药物疗法,包括抑郁症和焦虑症.
- 抗药物也经常在非标签上使用,突出其广泛的临床应用.
研究的目的:
- 分析25个欧洲国家的AD消费的当前和历史趋势.
- 预测未来的AD消费模式到2030年.
- 为了研究13个欧洲国家的特定AD子组的消费.
主要方法:
- 利用经合组织数据探索器从1980年到2024年获取AD消费数据 (ATC代码N06A).
- 从公共来源收集的子组数据.
- 雇佣的自动回归集成移动平均线 (ARIMA) 模型用于2030年的消费预测.
- 与抑郁症患病率相关的计算治疗覆盖率.
主要成果:
- 在2023年,AD消费的差异很大,从拉脱维亚的26.3 DID到冰岛的164.7 DID.
- 大多数国家看到AD使用增加,在拉脱维亚 (+157.8%) 和奥地利 (+5.9%) 显著增长. 预测显示大多数国家继续增加,匈牙利,奥地利,英国和卢森堡预计下降.
- 选择性色素再吸收抑制剂 (SSRI) 仍然是最常被处方的子组,而"多种"类别正在增长. 非选择性单胺再吸收抑制剂 (NSMRIs) 正在下降,而MAO-I/MAOA-I的使用量很少.
- 区域差异存在,北欧的AD使用率高于东欧,主要是由SSRI和各种子组偏好驱动的.
结论:
- 阿尔茨海默症的消费量正在增加,预计将进一步增加,随着药物子组的偏好不断变化.
- 短暂性兴奋剂的患病率与一线治疗指南一致,而增加的"多样性"使用可能表明个性化治疗方法.
- 减少NSMRIs和MAO-I/MAOA-I的有限使用,分别归因于不良影响和安全问题.
- 处方模式的区域差异受医疗保健系统,文化因素,耻辱和资源可用性的影响.
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