c-Myc调节的长非编码RNA TRD-AS1 影响口腔状细胞癌的进展

Ziyue Feng¹, Yuxuan Han¹, Xiaofeng Qin¹

¹College & Hospital of Stomatology,, Anhui Medical University, Anhui Provincial Key Laboratory of Oral Diseases Research,, Hefei, 230032, China.

Genes & genomics

|March 10, 2026

概括

c-Myc通过调节长非编码RNA TRD-AS1 (LNC TRD-AS1) 来促进口腔状细胞癌 (OSCC) 的进展. LNC TRD-AS1增强OSCC细胞迁移,增殖和新陈代谢,影响瘤酸代谢.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
基因规则基因规则

背景情况:

口腔状细胞癌 (OSCC) 的进展涉及复杂的瘤转录和非编码RNA网络.
c-Myc是癌症中的关键转录因子,但其对OSCC中TRD-AS1等长非编码RNA (lncRNAs) 的调节尚不清楚.

研究的目的:

阐明c-Myc在LNC TRD-AS1.1上的监管作用.
研究c-Myc调节的LNC TRD-AS1对OSCC进展的影响,包括细胞迁移,增殖和新陈代谢.

主要方法:

使用定量实时聚合酶链反应 (qRT-PCR) 和西部斑点来评估基因和蛋白质表达.
双 luciferase 记者测定证实了c-Myc 与 LNC TRD-AS1 促进体的结合.
细胞测试包括测试,Transwell测试,CCK-8和殖民地形成测试评估了细胞迁移,增殖和代谢变化.

主要成果:

发现c-Myc在OSCC组织和细胞系中积极调节LNC TRD-AS1表达.
LNC TRD-AS1主要定位在OSCC细胞的细胞核中.
过度表达LNC TRD-AS1增强了OSCC细胞的迁移,增殖和新陈代谢,而它的淘汰抑制了这些过程.

结论:

在OSCC中,c-Myc直接调节LNC TRD-AS1的表达.
LNC TRD-AS1在促进OSCC细胞迁移,增殖和改变瘤酸代谢方面发挥着重要作用.

关键词:

ENST000005567777777 是一个非常好的方法.LNC TRD-AS1 一个国家.长非编码RNA是什么意思口腔状细胞癌的癌症.c-Myccc 的意思是我的

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