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关于肝硬化患者药物选择和剂量调整的建议:多学科专家小组的结果

Katharina Karsten Dafonte1, Philipp Lutz2, Christian Jansen2

  • 1Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany. Katharina.Karsten_Dafonte@ukbonn.de.

Clinical drug investigation
|March 10, 2026
PubMed
概括

肝硬化药物剂量在专家之间显示出显著的变化,突出需要更清晰,协调的指导. 目前的做法往往缺乏共识,并且与官方处方信息不符.

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Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
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