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Updated: Mar 12, 2026

Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands
05:48

Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands

Published on: January 2, 2018

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NOTCH3 CADASIL 变体受体聚合需要NOTCH3 野生型受体:识别高度选择性的抑制剂,以阻止该过程

Haijiang Wang1,2, Xinxin Liu2, Gido Gravesteijn3

  • 1Department of General Surgery, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
|March 10, 2026
PubMed
概括

大脑自体主导动脉病变与皮下心脏病发作和白细胞脑病变 (CADASIL) 是由NOTCH3突变引起的. 致病变体促进NOTCH3受体聚合并增强信号传递,为新疗法提供点.

关键词:
卡达西尔 (CADASIL) 是一种在NOTCH受体抑制剂中.在NOTCH信号中发出信号.基于的抑制剂 基于的抑制剂蛋白质聚合蛋白质的聚合物有针对性的治疗.

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