药使用和急性损伤风险:对日本医院数据库的分析
Satoru Mitsuboshi1, Masami Tsuchiya2, Hayato Kizaki2
1Department of Pharmacy, Kaetsu Hospital, Niigata, Japan; Division of Drug Informatics, Keio University Faculty of Pharmacy, Tokyo, Japan.
The Journal of pharmacology and experimental therapeutics
|March 10, 2026
概括
这项研究发现,与氧化相比,在使用不同类型的药 (包括lubiprostone, senna和linaclotide) 的患者中,急性损伤 (AKI) 风险没有显著差异. 这些发现表明药选择可能不会影响AKI风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 松剂使用与急性损伤 (AKI) 之间的潜在联系需要进一步调查.
- 了解不同药类别中AKI的比较风险对于患者安全至关重要.
研究的目的:
- 调查使用特定的药 (卢比,林纳克洛提德,塞纳,氧化) 与发展AKI的风险之间的关联.
- 为了比较与分泌药物,刺激性药和非吸收物质相关的AKI风险.
主要方法:
- 使用JMDC医院行政索赔数据库 (2014年4月至2022年8月) 进行的回顾性队列研究.
- 定义的药包括 lubiprostone, linaclotide (分泌), senna (兴奋剂) 和氧化 (未被吸收).
- AKI诊断遵循病:改善全球结果 (KDIGO) 标准;使用了考克斯回归分析.
主要成果:
- 包括159,630名患者;不同组的AKI发病率各不相同.
- 考克斯回归显示,与氧化相比,lubiprostone (aHR,0.96), senna (aHR,1.08),或linaclotide (aHR,1.42) 的AKI风险没有统计显著降低.
- 调整后的危险比率表明,这些药对AKI发展没有保护作用.
结论:
- 该研究发现,在使用 lubiprostone, senna, linaclotide 或氧化的患者中,急性损伤风险没有显著差异.
- 这些发现表明,在这些药物中选择药可能不会显著影响发展AKI的风险.
- 进一步的研究可能是有必要的,以证实这些发现在不同的人群和临床环境.
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