循环IGF-1水平和27个消化系统疾病:461,401英国生物库前性分析
Wenwen Yang1, Jie Gao1, Zhixian Bao1
1The First Clinical Medical College, Lanzhou University, Lanzhou 730000, Gansu Province, China; Department of Gastroenterology, the First Hospital of Lanzhou University, Lanzhou, China.
胰岛素样生长因子-1 (IGF-1) 影响消化系统的健康. 低水平的IGF-1增加了19种消化系统疾病的风险,而非常高的IGF-1水平则增加了和等疾病的风险.
科学领域:
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 胰岛素样生长因子-1 (IGF-1) 对于胃肠粘膜修复,肝功能和代谢平衡至关重要.
- IGF-1水平与广泛的消化系统疾病之间的关系还不清楚.
研究的目的:
- 系统地调查循环IGF-1水平与各种消化系统疾病的风险之间的关联.
- 使用大规模数据集探索线性和非线性关联.
主要方法:
- 分析了461,401名英国生物库参与者 (40-69岁) 的IGF-1基线测量结果.
- 利用考克斯比例危险回归和受限立方线 (RCS) 分析来评估与27种ICD-10消化系统疾病的关联.
- 追踪数据收集到2024年8月 (中位数为66-184个月).
主要成果:
- 在IGF-1水平与17种消化系统疾病之间发现了不良关联.
- 过高的IGF-1水平与腹腔,麻性阴茎,肠道阻塞,分泌管疾病和风的风险增加有关.
- IGF-1 缺乏与 19 种消化系统疾病的更高风险有关,而 inguinal hernia 显示出非线性正相关性.
结论:
- IGF-1水平与消化系统疾病风险存在复杂的非线性关联.
- 无论是IGF-1缺乏还是过量都是有害的,强调某些消化系统疾病的U形或J形风险曲线.
- 研究结果强调IGF-1在维持消化系统健康和预防疾病方面的关键作用.
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