一种海生长的多糖:通过调节肠道微生物群来改善性结肠炎的结构和改善
Jing-Chun Sun1, Shu-Yao Wang1, Qiu-Na Nong1
1Shaanxi Key Laboratory of Natural Products & Chemical Biology, School of Chemistry & Pharmacy, Northwest A&F University, Yangling, 712100, China.
International journal of biological macromolecules
|March 10, 2026
概括
来自海皮皮的新型多糖,SBPP-BI,通过恢复肠道屏障功能和调节炎症,有效地治疗小鼠的性结肠炎 (UC). 这种天然化合物显示出作为UC管理的益生菌的前期承诺.
科学领域:
- 自然产品化学 自然产品化学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 性结肠炎 (UC) 涉及粘膜损伤,屏障破坏和肠道失生症,治疗选择有限.
- 海 (Hippophae rhamnoides) 已知对肠道有好处,但其骨中的生物活性化合物尚未得到充分探索.
- 多糖是UC干预的有希望的自然剂.
研究的目的:
- 为了隔离和表征一种生物活性多糖体,从海棘.
- 为了评估SBPP-BI的抗性结肠炎疗效.
- 在UC小鼠模型中阐明SBPP-BI治疗效果背后的机制.
主要方法:
- 隔离和净化SBPP-BI从海棘骨中.
- 使用先进的分析技术阐明SBPP-BI的结构.
- 在活体中评估SBPP-BI在硫酸诱导的大肠炎模型小鼠中.
- 对肠道微生物群,短链脂肪酸和炎症信号通路 (TLR4/NF-κB) 的分析.
主要成果:
- 一种具有复杂结构的同质多糖体,SBPP-BI (Mw = 62.0 kDa) 被分离出来.
- SBPP-BI显著改善了结肠炎症状,恢复了肠道屏障的完整性,并使炎症性细胞因子水平正常化.
- SBPP-BI调节了肠道微生物组成,增加了短链脂肪酸的产生,并抑制了TLR4/NF-κB的激活.
结论:
- SBPP-BI是一种新型的多糖化合物,来自海生,表现出显著的抗性结肠炎活性.
- 治疗效果归因于肠道屏障恢复,抗炎作用和微生物群调节.
- SBPP-BI具有作为治疗性结肠炎的益生菌剂的潜力.
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