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在延长子换间隔的同时保持福利:在IVC的小鼠中进行了一项基于绩效的研究.

Alessandro P Lamacchia1,2, Christin Herrmann3, Kevin M O'Brien1,2

  • 1University Laboratory Animal Resources, University of Pennsylvania, Philadelphia, Pennsylvania.

Journal of the American Association for Laboratory Animal Science : JAALAS
|March 10, 2026
PubMed
概括

延长老鼠换间隔的时间可以长达42天,没有改变,或84天,部分改变床单,这是可行的. 这项研究表明,较长的间隔不会对单独通风的子 (IVC) 中的动物健康或微环境产生负面影响.

关键词:
2M,每个子有两个雄性.IVC,个别通风的子NH3,氨是一种PBC,部分更换床单; 2F,每个子有两个雌性.

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科学领域:

  • 实验室动物科学实验室动物科学
  • 动物福利和畜牧业
  • 微环境管理的管理

背景情况:

  • 在单独通风的子 (IVC) 中进行标准的2周子更换是劳动密集的,并可能增加动物的压力.
  • 延长子更换间隔对于特定研究至关重要,例如病毒研究,但必须保持动物福利和微环境质量.

研究的目的:

  • 为了确定IVC的最大可接受的间隔,对双置小鼠的完整子变化.
  • 为了评估每两周一次的部分床位更换在延长子更换间隔中的有效性.
  • 评估延长间隔对微环境参数和动物健康的影响.

主要方法:

  • 野生型C57BL/6J小鼠 (8周大) 在各种条件下被安置在IVC中:没有床单更换 (长达42天),每两周一次的部分床单更换 (长达84天).
  • 监测了微环境参数 (氨,湿度,温度),视觉清洁,日常健康和鼻腔组织病理学.
  • 测试了不同的子密度和性别 (2 个雄, 2 个雌, 4 个雌).

主要成果:

  • 双双安置的雄性和雌性小鼠耐受42天没有子的变化,受限于脏的床单,而不是氨水水平或健康问题.
  • 每两周一次的部分床位更换允许在不超过微环境值的情况下住宿84天 (2雄/雌) 和62天 (4雌).
  • 在任何一组中都没有观察到氨诱导的损伤或其他疾病的显著组织病理证据.

结论:

  • 延长完整的子更换间隔到42天是可能的对住的小鼠.
  • 部分床铺变化可以显著延长住房期,在某些密度下,长达84天.
  • 减少子密度和部分床位变化支持扩展住房,而不会损害IVC中的动物福利或微环境.