在年轻人糖尿病自身免疫研究 (DAISY) 中,在1型糖尿病发病前表观遗传年龄加速的纵向变化
Kelly Bergstrom1, Harry Smith2, Randi K Johnson3,4
1Epidemiology, Colorado School of Public Health, Aurora, Colorado, USA Kelly.bergstrom@cuanschutz.edu.
BMJ open diabetes research & care
|March 10, 2026
概括
在岛屿自身免疫血清转换之前患有1型糖尿病的儿童中,表观遗传年龄加速 (EAA) 降低. 这表明早期的环境因素会影响1型糖尿病的发展.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- 1型糖尿病 (T1D) 的发病与生命早期的压力因素有关.
- 表观遗传衰老加速 (EAA) 与环境暴露和慢性疾病发展相关.
- 在高风险儿童中研究纵向EAA为T1D病因提供了洞察力.
研究的目的:
- 检查1型糖尿病高风险儿童表观遗传年龄加速 (EAA) 的纵向变化.
- 为了确定EAA是否在患有1型糖尿病的儿童和小岛自身免疫 (IA) 血清转换前后的对照之间有所不同.
主要方法:
- 分析了来自2547名高风险儿童的长度DNA甲基化数据 (年轻人群中的糖尿病自身免疫研究).
- 表观遗传年龄加速 (EAA) 用儿科特定的表观遗传时钟计算.
- 线性混合模型比较了85例T1D病例的EAA变化与85例对照,IA前后血清转化.
主要成果:
- 在T1D病例和对照组之间观察到EAA变化的显著差异 (p=0.02).
- 从IA前到IA后血清转换的T1D病例在EAA显著下降 (-0.367单位,p=0.01).
- 在对照组中没有检测到EAA显著变化 (0.045单位,p=0.75).
结论:
- 表观遗传年龄加速 (EAA) 变化发生在小岛自身免疫 (IA) 血清转换之前患有1型糖尿病的儿童中.
- 这些发现强调了早期环境压力因素在1型糖尿病病原发生中的潜在作用.
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