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Updated: Mar 12, 2026

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使用塞马格卢提德的缺血性视神经病变:对性别和配方特异性风险的全球观察分析

Moiz Lakhani¹, Abdullah Al-Ani², Marko Popovic³

¹Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.

The British journal of ophthalmology

|March 10, 2026

概括

葡萄糖类-1 (GLP-1) 受体激活剂,特别是黄,与缺血性视神经病变 (ION) 有关. 韦格维显示ION风险高于Ozempic,在男性中观察到的风险更大,这表明潜在的剂量依赖的安全问题.

科学领域:

药物监督药物监督药物监督
眼科医生眼科眼科
内分泌学在内分泌学.

背景情况:

缺血性视神经病变 (ION) 是一种罕见但严重的影响视力的并发症.
最近的证据表明GLP-1受体激动剂和ION之间的潜在关联.
在这些案例中,广泛使用的GLP-1受体激动剂塞马格卢提德 (Semaglutide) 参与其中.

研究的目的:

调查塞马格卢提德与缺血性视觉神经病变 (ION) 之间的配方和性别特定关联.
通过使用现实世界的数据,评估不同类型的塞马格卢提德配方的安全性.

主要方法:

从FDA不良事件报告系统 (2017-2024) 中分析了超过3000万份不良事件报告.
评估了31,774例西马格卢提德病例,比较了Wegovy和Ozempic.
性别分层分析和多变量回归以评估风险因素.

主要成果:

与Ozempic (ROR=18.81) 相比,Wegovy对ION (ROR=74.89) 显示出一个显著更强的信号.
与女性相比,男性的ION几率更高 (ROR=116.37),男性的ION几率更高.
多变量回归证实Wegovy与Ozempic (AOR=4.74) 和男性与女性 (AOR=3.33) 的风险增加.

结论:

调查结果表明,与ION相关的塞马格卢提德配方存在潜在的剂量依赖性安全问题.
男性的风险增加需要进一步调查.
迫切需要进行前性评估,以指导GLP-1受体激动剂的临床实践和监管政策.

关键词:

药物药物药物是一种药物.视神经神经神经神经神经视神经神经药理学药理学是指药理学的学科.公共卫生公共卫生视觉视觉视觉视觉视觉是一个

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