药物使用障碍中的精神病并发症:全国真实世界的临床样本中的基于性别的差异
Eduardo R Butelman1, Yuefeng Huang1, Rita Z Goldstein1
1Neuropsychoimaging of Addictions and Related Conditions, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York.
The American journal of psychiatry
|March 11, 2026
概括
与女性相比,有物质使用障碍 (SUD) 的男性焦虑,双相,抑郁和创伤障碍的几率较低,但精神病障碍的几率较高. 在精神病的伴随性疾病中,这些性别差异因SUD类型而异.
科学领域:
- 精神病学是一个精神病学.
- 成 药物 药物 药物 药物
- 临床心理学 临床心理学
背景情况:
- 药物使用障碍 (SUD) 经常与精神病共同发生.
- 现有的研究表明,在这些并发症中,性别差异不一致.
- 了解这些差异对于定制治疗至关重要.
研究的目的:
- 在阿片类药物,酒精或大麻依赖的个体中调查基于性别的精神病并发症差异.
- 分析不同SUD群体中与性别相关的特定精神疾病 (焦虑,双相,抑郁,精神病,创伤相关) 的几率.
主要方法:
- 国家临床数据集的横截面分析 (2022年).
- 包括首次诊断为阿片类药物 (N=28,808),酒精 (N=23,281) 或大麻依赖 (N=5,961) 的成年人 (≥18岁).
- 多项逻辑回归检查了性别,种族,种族和年龄作为精神病相关疾病的预测因素.
主要成果:
- 与女性相比,患有阿片类药物,酒精或大麻依赖的男性患焦虑,双相,抑郁和创伤相关疾病的几率较低.
- 患有阿片类药物或大麻依赖的男性患精神分裂症或其他精神疾病的几率高于女性.
- 种族和种族也与特定的并发症有关.
结论:
- 在阿片类药物,酒精和大麻使用障碍之间的精神病并发症中存在显著的基于性别的差异.
- 这些发现凸显了在SUD和精神疾病的背景下考虑性别的必要性.
- 建议对个性化护理的潜在生物心理社会机制进行进一步的研究.
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