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Updated: Mar 12, 2026

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对于晚年抑郁症的背侧侧前额叶皮层区域的双边theta爆发刺激:一个随机化,假冒控制的临床试验

Leandro da Costa Lane Valiengo^1,2,3,4, Bianca Silva Pinto¹, Matthias Luethi¹

¹Service of Interdisciplinary Neuromodulation, Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo Medical School, São Paulo, Brazil.

The American journal of psychiatry

|March 11, 2026

概括

泰达爆发刺激 (TBS) 显示出对晚年抑郁症的有希望. 虽然在第6周没有显著差异,但与假药治疗相比,活跃TBS在第12周改善了抑郁症状.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
老年学是一门学科.

背景情况:

晚年抑郁症 (LLD) 构成了重大挑战,往往需要新的治疗方法.
现有的LLD治疗方法在老年人中可能具有有限的疗效或显著的副作用.

研究的目的:

评价泰达爆发刺激 (TBS) 作为60岁及以上人中中度至重度重度抑郁症治疗的有效性.
为了比较活跃TBS与假TBS在减少晚年人口中抑郁症状的疗效.

主要方法:

进行了一项三重盲目的,模拟控制的随机临床试验.
108名参与者 (平均年龄67岁) 患有LLD,不服用抗抑郁药,在23次会议中接受了活跃或假的TBS.
TBS涉及双边刺激,左侧的DLPFC有间歇性TBS,右侧的DLPFC有连续性TBS.

主要成果:

在第6周,在活跃TBS和假TBS之间没有观察到汉密尔顿抑郁评分表 (HAM-D) 评分降低的显著差异.
到第12周,活跃的TBS显示HAM-D得分的显著降低比假的要大得多.
在第12周,活性TBS的响应率为52%,而假TBS的响应率为33%.

结论:

活跃TBS在减轻12周晚期抑郁症患者的抑郁症状方面优于假刺激.
对于患有晚年抑郁症的人来说,TBS代表了一个潜在的治疗选择.
进一步的研究可能会探索LLD中TBS的长期疗效和最佳参数.

关键词:

抑郁症抑郁症抑郁症抑郁症老年精神病学是一门精神病学专业.神经刺激是一种神经刺激.通过骨磁性刺激 (TMS) 进行.

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