相关实验视频

Updated: Mar 12, 2026

Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C UV-C Damage

Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C UV-C Damage

Published on: February 15, 2020

氧化性DNA损伤和抗氧化剂耗尽:初级开角玻璃眼中一个全身形状

Author Kubra Akyol¹, Author Ibrahim Kocer², Halil İbrahim Ozkan³

¹Department of Ophthalmolog, Kahramankazan State Hospital, Atatürk Mahallesi Osmanlı Caddesi, Ankara, Türkiye.

Korean journal of ophthalmology : KJO

|March 11, 2026

概括

患有初级开角青光眼 (POAG) 的患者表现出全身氧化应激,如MDA和8-OHdG等较高的损伤标志物和CoQ10和维生素D等较低的抗氧化剂.这种不平衡与POAG有关,但与疾病严重程度无关.

科学领域:

眼科医生眼科眼科
生物化学生化学
氧化压力研究研究氧化压力研究

背景情况:

主要开角青光眼 (POAG) 是不可逆转失明的主要原因.
氧化压力与各种疾病的发病有关,包括青光眼.
在POAG患者中,氧化应激的全身标志物尚未得到广泛研究.

研究的目的:

为了研究POAG患者的全身氧化应激.
在POAG患者和健康对照者之间比较血清中8-基-2'-脱氧氨酸 (8-OHdG),辅酶Q10 (CoQ10),氨酸 (MDA) 和25-基维生素D (25(OH) D的水平.

主要方法:

一项前性病例控制研究,涉及37名POAG患者和35名健康对照.
血清生物标志物水平使用酶相关免疫吸收试验量化.
统计分析包括曼-惠特尼U测试,斯皮尔曼相关性和多变量线性回归.

主要成果:

在POAG患者中,MDA和8-OHdG水平显著提高 (P<0.05).
在POAG患者中,CoQ10和25OH) D水平显著降低 (P<0.05).
在MDA和8-OHdG之间观察到强烈的正相关性 (ρ = 0.855,P < 0.001).
在对年龄和性别进行调整后,POAG状态独立地与较低的CoQ10水平相关 (P < 0.001).

结论:

POAG患者表现出全身氧化失衡,氧化损伤增加和抗氧化能力降低.
观察到的系统性失衡与POAG有关,但与临床疾病严重程度无关.
这些发现表明POAG的潜在系统成分,而不是疾病严重程度的直接标志物.

关键词:

8-基-2′-脱氧氨酸是什么?辅酶Q10是一种辅酶.眼光障碍症眼光障碍症眼光障碍症马隆迪阿尔化物氧化应激是一种氧化应激.维生素D 维生素D是一种维生素.

更多相关视频

Quantification of Reactive Oxygen Species Using 2′,7′-Dichlorofluorescein Diacetate Probe and Flow-Cytometry in Müller Glial Cells

Quantification of Reactive Oxygen Species Using 2′,7′-Dichlorofluorescein Diacetate Probe and Flow-Cytometry in Müller Glial Cells

Published on: May 13, 2022

Comet Assay as an Indirect Measure of Systemic Oxidative Stress

Comet Assay as an Indirect Measure of Systemic Oxidative Stress

Published on: May 22, 2015

相关概念视频

Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...