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在微生理系统中控制细胞空间组织的策略.

Hung Dong Truong1, Zhixing Ge2, Elgene Chng2

  • 1Department of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore. hung.truongbme@gmail.com.

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概括

空间组织对于组织功能至关重要. 本综述探讨了控制微生理系统 (MPS) 中细胞定位的直接和间接方法,以更好地模拟疾病和药物查.

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科学领域:

  • 组织工程和再生医学.
  • 细胞生物学和生物物理学
  • 微生理系统 (MPSs) 的发展发展.

背景情况:

  • 组织生理学依赖于微型架构中的细胞的精确空间组织.
  • 微生理系统 (MPS) 旨在模仿人类组织,但往往缺乏空间控制,阻碍了准确的功能复制.
  • 自然组织的发育涉及复杂的化学和机械线索,指导细胞的安排.

研究的目的:

  • 审查和分类空间模式策略,以加强微生理系统 (MPSs).
  • 为了突出空间真实性在复制组织复杂性的重要性 in vitro.
  • 讨论疾病建模,发育生物学和药物查中的应用.

主要方法:

  • 将空间模式分为直接方法 (如3D生物打印,微流体) 和间接方法 (如ECM组合,机械梯度) 的分类.
  • 分析物理放置细胞和隔间的技术.
  • 检查细胞对工程环境线索的反应.

主要成果:

  • 直接方法在细胞放置方面提供了精度和可重复性.
  • 间接方法更好地模仿自然的自我组织过程.
  • 这两种方法都适用于各种生物结构,包括接口,屏障组织和宿主微生物系统.

结论:

  • 改善MPS的空间忠实性对于复杂组织组织的复杂组织组织是必不可少的.
  • 在MPS中增强空间控制将显著推进疾病建模和药物发现.
  • 未来的研究应该专注于整合直接和间接的空间模式策略,以获得更具生理相关性的模型.