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暴露于寒冷会增加通过细胞外冷诱导性RNA结合蛋白和类似受体4信号的收费增加大动脉剖析风险

Hsiao-Ya Tsai¹, Wu-Chien Chien^2,3,4, Chi-Hsiang Chung^2,3,4

¹Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical University, No. 325, Sec. 2, Cheng-Kung Road, Neihu District, Taipei City, 114, Taiwan.

Scientific reports

|March 11, 2026

概括

寒冷的天气增加了大动脉解剖 (AD) 的风险. 寒冷压力和细胞外冷诱导性RNA结合蛋白 (eCIRP) 通过激活托尔类受体4 (TLR4) 途径,使AD恶化. 阻止eCIRP是一种潜在的治疗方法.

科学领域:

心血管研究研究心血管研究
免疫学免疫学免疫学
环境健康环境健康

背景情况:

观察性研究将寒冷的天气与心血管疾病风险增加联系起来.
冷诱导型RNA结合蛋白 (CIRP) 具有保护作用,但细胞外CIRP (eCIRP) 作为危险信号触发炎症.
了解寒冷压力对血管健康的影响对于预防紧急情况至关重要.

研究的目的:

为了研究低温与大动脉剖析 (AD) 发展之间的关联.
阐明将寒冷压力与血管细胞损伤联系在一起的机制.
探索eCIRP作为感冒引起的血管紧急情况的治疗目标.

主要方法:

分析气象数据和医疗保险索赔,以将低温与AD相关联.
使用3-aminopropionitrile fumarate (BAPN) 和急性寒冷暴露 (ACE) 建立一种小鼠AD模型.
在体外对内皮细胞的研究和在体内对CIRP抗剂的实验.

主要成果:

寒冷压力和ecirp诱导了血管炎症和通过托尔类受体4 (TLR4) 途径的矩阵金属蛋白酶-2过度表达.
在较低的温度下观察到AD的发病率更高.
在接受BAPN治疗的小鼠中,ACE加剧了AD,增加了大动脉直径和炎症标志物;C23,一种CIRP对手,显示出保护作用.

结论:

低温与AD的发展有关,特别是在特定的气候条件下.
细胞外CIRP (eCIRP) 通过eCIRP/TLR4通路调解冷压引起的AD恶化.
抑制eCIRP是一种有前途的治疗策略,可以应对感冒引起的血管紧急情况.

关键词:

大动脉动脉瘤是一个大动脉动脉瘤.动脉剖析是一个大动脉剖析.冷诱导的RNA结合蛋白质是冷诱导的RNA结合蛋白质.寒冷的压力是冷的压力.矩阵金属蛋白质酶的结构.收费类受体-4的收费类受体-4

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