在健康参与者中,从吸入的甘丁乙烯 (PGBE) 和甘甲基乙烯 (PGME) 排泄出尿中的代谢物
Nancy B Hopf1, Susanne Kaspar2, Jamal Bouitbir3
1Department for Occupational and Environmental Health, Unisanté, University Center for Primary Care and Public Health & University of Lausanne, Route de la Corniche 21, 1010, Lausanne, Switzerland. Nancy.Hopf@unisante.ch.
乙醇乙烯 (PGEs) 可以代谢成有害的氧酸. 这项研究在暴露后在尿液中检测到这些代谢物,突出显示了商业产品中β-异构体的风险.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 职业健康 职业健康 职业健康
背景情况:
- 甘乙烯,包括乙烯甘乙烯 (PGEs),是常见的两性有机溶剂.
- PGEs存在作为α和β异构体;由于毒性问题,一些PGEs的β异构体受到限制.
- 商业PGE,如乙醇单甲基乙烯 (PGME) 和乙醇单乙烯 (PGBE),在产品中广泛使用,并且很容易被人体吸收.
研究的目的:
- 为了研究烯基醇单乙烯 (PGBE) 转化为2-丁基酸 (2-BPA) 的新陈代谢.
- 在受控暴露于PGBE和PGME后,在人类参与者中量化尿中的2-BPA和其他代谢物.
- 评估PGEs中的β-异构体代谢的毒理学影响.
主要方法:
- 在体外肝细胞实验中证实了PGBE对2-BPA的代谢.
- 人类受控暴露研究 (N=17) 涉及2小时吸入蒸汽混合物 (15 ppm PGBE,35 ppm PGME).
- 使用四极质谱学 (LC-MS/MS) 的液体染色学量化尿中代谢物的量化.
主要成果:
- 实验室研究证实PGBE会被代谢成2-BPA.
- 与PGME相比,PGBE暴露的尿中代谢物度更高.
- 在人类参与者中,尿路代谢物清除的峰值发生在暴露后1小时.
- 该研究在PGE暴露后检测到尿液中的β-异构体代谢物.
结论:
- 含有β-异构体的商业乙烯基醇可以很容易地代谢成可能有害的氧酸.
- 检测到的尿路代谢物证实了β-异构体的体内代谢.
- 目前的毒理学评估可能不足以解决与PGEs中的β-异构体代谢相关的健康风险.
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