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Updated: Mar 12, 2026

Chemo-enzymatic Synthesis of N-glycans for Array Development and HIV Antibody Profiling
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ALG3/9/12的结构揭示了N-glycan oligomannose核心的组装逻辑

J Andrew N Alexander1, Shu-Yu Chen2, Somnath Mukherjee3

  • 1Institute of Molecular Biology and Biophysics, Eidgenössische Technische Hochschule (ETH) Zürich, Zurich, Switzerland.

Nature chemical biology
|March 11, 2026
PubMed
概括

这项研究揭示了关键酶 (ALG3,ALG9,ALG12) 在合成内 плазма网膜中必不可少的N链 glycans 的精确分子机制. 了解这个过程可以解释血糖化 (CDG) 的先天性障碍,并有助于N-glycan工程.

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