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Updated: Mar 12, 2026

NMR-Based Fragment Screening in a Minimum Sample but Maximum Automation Mode
09:19

NMR-Based Fragment Screening in a Minimum Sample but Maximum Automation Mode

Published on: June 4, 2021

3.9K

在源碎片化最小化用于基于质谱的NDSRI分析程序:一个Nitroso-bumetanide的案例研究

Jinhui Zhang1, Mack Shih2, Jingyue Yang2

  • 1Office of Pharmaceutical Quality Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, Maryland, 20993, USA. Jinhui.Zhang@fda.hhs.gov.

The AAPS journal
|March 11, 2026
PubMed
概括

在液态染色体质谱法 (LC-MS) 中的源内碎片化 (ISF) 可以影响尼托拉胺药物物质相关杂质 (NDSRI) 的测量. 这项研究表明,如何在分析方法开发过程中最大限度地减少ISF,以获得准确的NDSRI量化.

关键词:
NDSRI (尼胺药物物质相关的杂质)分析程序开发 分析程序开发在源头碎片化中.质谱测量质谱测量质谱测量质谱测量质量测量质谱测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量之前的知识 之前的知识风险评估 风险评估 风险评估

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