近红外光生物调节可以缓解化疗诱导的外围神经病变相关的感官异常
Zejun Ren1, Hengtong Fan1, Yuhang Chen2
1Department of Urology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Journal of photochemistry and photobiology. B, Biology
|March 11, 2026
概括
光生物调制 (PBM) 疗法通过促进神经修复和减少炎症,有效治疗化疗诱导的周围神经病变 (CIPN). 这种非侵入性方法为管理CIPN症状提供了一个有希望的替代方案.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 在瘤学瘤学.
背景情况:
- 化疗诱导的周围神经病变 (CIPN) 是帕克利塔塞尔治疗的削弱性副作用.
- 目前对CIPN的治疗选择有限,并且往往是无效的.
- 使用近红外光的光生物调制 (PBM) 显示了神经再生和抗炎作用的潜力.
研究的目的:
- 在临床前CIPN模型中评估PBM的治疗疗效.
- 调查PBM对CIPN的影响背后的分子机制.
- 评估PBM对神经修复,炎症和线粒体功能的影响.
主要方法:
- 建立了CIPN的小鼠模型,并用808nm近红外PBM治疗了三个星期.
- 进行了体内行为评估,皮内神经纤维密度分析和线粒体超结构评估.
- 在实验室中使用了N2a神经母细胞瘤和NHA细胞模型,这些细胞暴露于带有或没有PBM的nab-paclitaxel,以评估细胞活力,炎症,氧化应激,线粒体功能和亡.
主要成果:
- 在CIPN小鼠中,PBM显著降低了过敏度,并恢复了神经纤维密度.
- PBM治疗保留了线粒体的超结构,并减少了氧化损伤.
- 在体外,PBM增强了神经元的增殖,减少了促炎性细胞因子,减弱了氧化应激,稳定了线粒体潜能,增加了ATP的产生,并通过线粒体通路抑制了细胞亡.
结论:
- 近红外PBM是一种有效的非药物治疗CIPN.
- PBM促进神经修复,减少神经炎症和氧化应激,并保持线粒体功能.
- 需要进一步的临床研究来探索PBM作为CIPN管理的治疗选择.
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