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Updated: Mar 12, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

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综合性临床前策略的药理动力学概况和候选人选择的3-基胺胺:一个有希望的抗疟疾类别

Alena Moritz1, Bastian Hirn-Derksen2, Saskia Klein3

  • 1Individualized Pharmacotherapy, Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Corrensstr. 48, 48149, Münster, Germany.

Malaria journal
|March 11, 2026
PubMed
概括

新型抗疟疾药TKK130在小鼠中显示出有前途的药理动力学和疗效,使其成为进一步开发抗疟原寄生虫的强有力的候选者. 这项研究使用in silico,in vitro和in vivo测试指导化合物选择.

关键词:
药物开发 药物开发疟疾:疟疾是一种疾病.药理动力学 药理动力学基于生理学的药物动力学建模.临床前 临床前

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High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry10:17

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