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Updated: Mar 12, 2026

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通过TNF和IFNG组合增强人体成熟寡类细胞的髓化潜力

Abdulshakour Mohammadnia1, Qiao-Ling Cui1, Moein Yaqubi1

  • 1Department of Neurology and Neurosurgery, Neuroimmunology Unit, Montreal Neurological Institute, McGill University, 3801 Rue University, Montréal, QC, H3A 2B4, Canada.

Journal of neuroinflammation
|March 11, 2026
PubMed
概括

瘤亡因子α (TNF) 和干扰素玛 (IFNG) 在多发性硬化症模型中共同促进寡干细胞修复. 这种组合增强了髓化基因表达,并逆转了炎症损伤,表明了治疗潜力.

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Nervous Tissue: Myelin01:25

Nervous Tissue: Myelin

The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
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