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Updated: Mar 12, 2026

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通过增强的分子模拟揭示了改进的CGRP结动学的决定因素

Ceren Kilinc1, Katie M Babin2, Augen A Pioszak2

  • 1Michigan State University, Department of Biochemistry and Molecular Biology, East Lansing, Michigan 48824, USA.

Biophysical journal
|March 11, 2026
PubMed
概括

工程化酸具有较长的结合时间,与类受体类受体:受体活性修饰蛋白1 (CLR:RAMP1) 复合体结合. 这种增长的停留时间对于药物疗效至关重要,源于改进的连接物重新捕获和稳定相互作用.

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