孕育后的怀孕时间和随后的怀孕结果:一个回顾性队列研究
Bar Rosh1,2, Joul Hadad3, Naomi Gronich1,4
1Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
概括
怀孕在子宫外怀孕 (EP) 治疗后的1-3个月内怀孕是安全的. 这项研究发现,试图怀孕早于6个月时,胎儿重大形或产科不良结果的风险不会增加.
科学领域:
- 生殖医学 生殖医学
- 药理学 药理学是指药理学的学科.
- 产科和妇科 产科和妇科
背景情况:
- 甲托雷克萨特是一种常见的异胎妊娠 (EP) 治疗方法.
- 由于人们担心甲醇的致死性,因此对治疗后怀孕的最佳时间产生不确定性.
- 目前的指导方针建议3个月的洗,而制造商建议6个月,关于早期怀孕安全性的证据有限.
研究的目的:
- 为了评估EP治疗后1-3个月内怀孕的安全性,与较长的间隔相比.
- 评估重大先天性形,自发流产,早产和低出生体重的风险.
主要方法:
- 对711名女性进行了回顾性队列研究,这些女性接受了EP治疗 (2010-2021年) 的甲索特雷克萨特治疗.
- 根据治疗后的受孕间隔分类的怀孕:1-3个月,3-6个月和>6个月.
- 经调整的赔率比率 (aORs) 是使用一般化估计方程计算的.
主要成果:
- 怀孕组之间主要先天性形没有统计学意义上的差异 (aOR为0.87为1-3个月,1.01为3-6个月与>6个月).
- 在1-3个月的组中,数字上较高的发育不良,早产和低出生体重率在统计学上并不显著.
- 总共分析了711例病例,其中38例在1-3个月内怀孕.
结论:
- 怀孕 1-3和3-6个月后的美托特雷克萨特对于EP似乎不会增加胎儿重大形的风险.
- 没有观察到其他不良产科结果的风险增加.
- 建议进行更大规模的前性研究,以进一步验证这些发现.
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