印度人口中中枢神经系统的侵入性菌感染:一个队列研究 (2004-2025)
Harsimran Kaur1, Shivaprakash M Rudramurthy1, Rimjhim Kanaujia2
1Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
The Lancet regional health. Southeast Asia
|March 11, 2026
概括
中枢神经系统侵袭性菌感染 (CNS IMI) 影响9.6%的脑样本,其中阿斯伯吉路斯和克拉多菲洛福拉是常见的罪祸首. 完整的外科切除和避免部分切除是改善患者生存结果的关键.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 神经学 神经学
背景情况:
- 中枢神经系统 (CNS) 侵袭性菌感染 (IMI) 是一种罕见的,危及生命的疾病.
- 关于中枢神经系统IMI临床特征和管理的有限的大规模研究存在.
- 这项研究提供了关于印度一家三级医院中枢神经系统IMI的见解.
研究的目的:
- 分析中枢神经系统IMI的临床,人口和真菌学特征.
- 为了比较成人和儿科患者之间的结果.
- 确定与中枢神经系统IMI死亡相关的因素.
主要方法:
- 在2004年1月至2025年3月期间,对127名确诊的中枢神经系统IMI患者进行了回顾性队列研究.
- 收集的数据包括临床表现,微生物学和组织病理学发现,治疗和结果.
- 进行了统计分析,以比较患者群体并确定预后因素.
主要成果:
- 在9.6%的脑/活检样本中发现了真菌病原体.
- 亚斯伯菌 spp. 的种类. (56.3%) 和Cladophialophora bantiana (21.36%) 是最常见的真菌.
- 总体死亡率为30.7%; 完全的外科切除与生存有显著的关联.
- 缺乏头痛和部分切除与糟糕的结果有关.
结论:
- 中枢神经系统IMI在印度呈现出明显的临床模式,因年龄和真菌类型而异.
- 完整的外科切除对于改善中枢神经系统的存活率至关重要.
- 对印度宿主和病原体因素的进一步研究是有必要的.
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