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在长期计算机断层扫描 (CT) 随访的基础上,对切除的亚固体肺腺癌中生长异质性和遗传突变之间的相关性分析

Shulei Cui¹, Linlin Qi¹, Fenglan Li¹

¹Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Translational lung cancer research

|March 11, 2026

概括

肺部亚固体结节 (SSN) 的生长与侵入性腺癌 (IA) 和表皮生长因子受体 (EGFR) 突变有关. 虽然EGFR驱动SSN生长,但它不调节生长速度,为个性化肺癌管理提供了洞察力.

科学领域:

肺部医学肺部医学
在瘤学瘤学.
放射学放射学是一门学科.
遗传学遗传学是一个

背景情况:

持久性肺部亚固体结节 (SSN) 可能是癌前或侵入性腺癌 (IA).
虽然SSN的生长模式各不相同,但其潜在的分子机制尚未得到充分理解.
长期的计算机断层扫描 (CT) 随访对于监测SSN行为至关重要.

研究的目的:

调查肺部SSN生长模式与常见基因突变之间的相关性.
使用长期CT随访数据,识别影响SSN生长的关键基因.
探索潜在的生物标志物和SSN管理的治疗目标.

主要方法:

具有≥3年CT随访或在3年内增长的SSNs的回顾性分析.
病理诊断和基因检测 (EGFR,KRAS,BRAF) 对于注册的SSNs.
统计分析包括曼·惠特尼U测试,奇二测试,费舍尔精确测试和后勤回归.

主要成果:

与不增长的SSN (13.3%) 相比,增长的SSN显示IA (82.8%) 的流行率明显更高.
EGFR突变与SSN生长有显著的关联,并且在IA中比非侵入性病变更频繁.
在快速生长和缓慢生长的SSN之间,EGFR,KRAS或BRAF_V600E突变率没有显著差异.

结论:

在CT上增加的SSN与侵入性腺癌和EGFR突变有显著的相关性.
在推动SSN增长方面,EGFR似乎起着关键作用,但在调节SSN增长速度方面却没有.
结果可能有助于个性化管理,生物标志物发现和SSN患者的治疗目标识别.

关键词:

亚固体结节 (SSN) 是指亚固体结节的组成部分.后续行动后续行动基因突变是一种基因突变.增长率增长率的增长速度是什么音量翻倍时间 (VDT)

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