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Updated: Mar 12, 2026

Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity
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GCDCA通过S1PR2/PI3K/AKT介导的M2型巨细胞的极化促进肝细胞癌的进展

Mengmeng Xue1,2,3, Wei Yu3, Kuizhi Zhang1,2,3

  • 1School of Pharmacy, Anhui Medical University, Hefei, China.

Frontiers in immunology
|March 11, 2026
PubMed
概括

甘油脱氧胆酸 (GCDCA) 通过重编程巨细胞来促进肝细胞癌 (HCC). 这种胆汁酸激活S1PR2/PI3K/AKT通路,增强M2巨细胞极化和瘤微环境中的癌症干细胞干性.

关键词:
在S1PR2受体中,S1PR2受体是葡萄糖基二氧化醇酸 (glycochenodeoxycholic acid) 是一种可靠的药物.肝细胞癌是肝细胞癌.巨细胞的两极分化树干性 树干性

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