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人类外周血液单细胞子集中的与年龄相关的化学因受体表达特征预测心血管疾病风险

Ravi K Komaravolu¹, Nandini Chatterjee², Sunil Kumar¹

¹Immunology Center of Georgia, Augusta University, Augusta, GA, United States.

Frontiers in immunology

|March 11, 2026

概括

衰老会改变单细胞化学因受体表达,影响冠状动脉疾病 (CAD) 的严重程度. 这些免疫变化可能会推动CAD的进展,提供新的治疗点.

科学领域:

免疫学免疫学免疫学
心血管疾病心血管疾病
衰老研究研究衰老研究

背景情况:

衰老显著导致慢性炎症和冠状动脉疾病 (CAD).
年龄对单细胞化学因受体表达的确切影响及其与CAD严重程度的联系尚未完全理解.

研究的目的:

调查衰老如何影响单细胞化学因受体表达与冠状动脉疾病严重程度相关.
在CAD患者中识别与年龄和疾病相关的单细胞免疫特征.

主要方法:

来自61名参与者 (年龄在42-78岁之间) 外围血液单核细胞的高维单细胞抗体测序 (Ab-Seq).
流细胞计验证和对特定单细胞子集的转录组分析.
与临床参数的相关性分析,包括CAD严重程度和脂质资料.

主要成果:

衰老重塑了单细胞群体,减少了抗炎经典单细胞和扩大不成熟单细胞.
特定的单细胞子集 (例如,iMo_HLA-DRintCCR2low,cMo_CD33hiCD163hiCXCR4+) 在年轻和年长的个体中显示出不同的CAD严重程度的改变表达.
在严重的CAD中,表达CXCR3的中间单细胞增加,独立于年龄,与C1Q基因表达相关.

结论:

单细胞化学因受体表达的明显变化与衰老和CAD严重程度有关.
这些与年龄和疾病相关的单细胞特征可能在冠状动脉疾病的进展中发挥作用.
这些发现突出了在老年人群中治疗CAD的潜在免疫点.

关键词:

阿布塞克 (Ab-Seq) 是一个词.根西尼的得分是什么? 根西尼的得分是什么?生物标志物生物标志物心血管疾病心血管疾病化学因子受体化学因子受体免疫衰老免疫衰老这是一种炎症炎症炎症炎症.单细胞 (Monocytes) 是一种单细胞.

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