对肝移植接受者药物相关问题和药剂师干预措施的前性评估
Sena Güzel Karahan1, Mefküre Durmuş2, Ahmet Çakır1
1Department of Clinical Pharmacy, Faculty of Pharmacy, Inonu University, Malatya, Türkiye.
Frontiers in pharmacology
|March 11, 2026
概括
肝移植患者经常出现与药物相关的问题 (MRPs). 剂量和药物选择问题是最常见的原因,突出了临床药剂师干预的领域.
科学领域:
- 药理学 药理学是指药理学的学科.
- 移植医学 移植医学
- 患者安全 患者安全
背景情况:
- 与药物相关的问题 (MRPs) 对住院患者构成重大风险,包括降低生活质量和增加死亡率.
- 肝移植接受者由于复杂的移植后护理要求,特别容易受到MRP的侵害.
- 临床药剂师对于管理MRP和确保合理使用药物至关重要.
研究的目的:
- 在住院肝移植接受者的MRPs的特征.
- 确定与这种人群中MRP发生相关的临床决定因素.
主要方法:
- 一项前性研究,涉及373名住院肝移植接受者.
- 使用了欧洲药物护理网络 (PCNE) 分类系统版本9.1.1.
- 患者特征的统计比较和风险因素分析的后勤回归.
主要成果:
- 在373名患者中,至少在311名 (83.4%) 患者中发现了至少一个MRP,总共620名MRPs.
- 最常见的原因是"剂量选择" (44.2%) 和"药物选择" (26.1%).
- 伴随性疾病和急性损伤是MRP的重要风险因素 (p < 0.05).
结论:
- 这是第一个使用PCNE v.9.1对病房和ICU环境中住院的肝移植患者进行的综合性研究.
- 与"治疗有效性"相关的流行MRPs强调需要集中注意力在剂量和药物选择上.
- 临床医生应谨慎对待患有并发症和有急性损伤史的移植受体.
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