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Updated: Mar 12, 2026

Xenopus laevis as a Model to Identify Translation Impairment
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Xenopus laevis as a Model to Identify Translation Impairment

Published on: September 27, 2015

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佐xaboroles是结构独特的结合剂的真核转化启动因子4E

Joshua B Combs, D Matthew Peacock, Gregory B Craven

    bioRxiv : the preprint server for biology
    |March 11, 2026
    PubMed
    概括

    佐xaborol化合物选择性地与真核转化启动因子4E (eIF4E) 结合,这是一个具有挑战性的药物标. 这种相互作用发生在mRNA帽结合口袋中,为小分子药物开发提供了新的途径.

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    Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells08:47

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    Rapid In Vivo Fixation and Isolation of Translational Complexes from Eukaryotic Cells14:29

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