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一种基于扩散的3D打印策略,用于制造自支持的,可透气的网络.

Daniel Ramos Mejia1, Betty Cai1, Sean Chryz Iranzo1

  • 1Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305 USA.

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概括

我们开发了嵌入式3D打印中统一接口扩散剂的凝 (GUIDE-3DP),这是一种创新的3D生物打印方法,用于创建自助式,可 perfusable 血管网络. 这种技术可以精确控制组织工程应用的通道尺寸和复杂几何形状.

关键词:
生物制造的生物制造生物打印是一种生物打印技术.可透的结构可以透.血管模拟器模仿了血管.

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科学领域:

  • 生物打印和组织工程
  • 生物材料科学 生物材料科学
  • 血管化策略 血管化策略

背景情况:

  • 工程血管系统对于功能性组织生物制造至关重要.
  • 三维 (3D) 生物打印为创建可 perfusable,定制的血管结构提供了一个有希望的方法.
  • 传统的牺牲油墨挤出方法在制造自支的船形外方面面临着挑战.

研究的目的:

  • 引入一种新的3D生物打印方法,GUIDE-3DP,用于制造自支持的,可 perfusable 血管网络.
  • 为设计,打印和内皮化血管类结构提供端到端的协议.
  • 为了证明 GUIDE-3DP 方法在创建复杂的可 perfusable 架构方面的适应性.

主要方法:

  • 在嵌入式3D打印 (GUIDE-3DP) 中开发了使用交叉连接启动器扩散的统一接口扩散剂的凝结.
  • 建立了一个协议,包括自由形式的打印路径设计,专用油墨和支持浴的准备,以及3D打印.
  • 嵌入内皮细胞播种,用于创建功能化的血管结构.

主要成果:

  • 成功制造出自支,可 perfusable 血管网络,精确控制内外通道直径.
  • 证明了复杂几何结构的制造,包括视网膜血管结构,层次分支网络和双材料毛细管状网络.
  • 使用单细胞或双细胞类型成功实现印刷结构的内皮质化.

结论:

  • 根据GUIDE-3DP的方法,可以制造出具有复杂设计的自支,可 perfusable 血管网络.
  • 该协议具有多功能性和适应性,可以创建超出血管模拟的各种可 perfusable 结构.
  • 这一进步对组织工程和再生医学应用具有重大潜力.