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Updated: Mar 12, 2026

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
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DDI2的损失通过CCN1驱动的补偿性自细胞转换蛋白质稳定

Nayyerehalsadat Hosseini1,2,3, Ahmed M Elshazly1,4,5, Holly A Byers1,2

  • 1Department of Pathology, Virginia Commonwealth University, Richmond, VA, USA.

iScience
|March 11, 2026
PubMed
概括

丢失DDI2蛋白质降解穿会导致有毒的CCN1积累,引发细胞应激和自. 这揭示了ubiquitin-proteasome系统和自-溶酶体通路之间的新联系,提供了治疗点.

关键词:
生物化学 生物化学生物科学 生物科学癌症 癌症 癌症 癌症癌症系统生物学癌症系统生物学蛋白质组学是指蛋白质组学.

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