社会大脑中早期微生物群破坏引起的缺陷对饮食敏感
Anna Ratsika1,2, Cristian A Bergmann1, Benjamin Valderrama1,2
1APC Microbiome Ireland, Biosciences Institute, University College Cork, Cork T12 YT20, Ireland.
iScience
|March 11, 2026
概括
饮食中的益生菌和牛奶生物活性成分逆转了小鼠的抗生素诱导的社会缺陷. 综合补充剂独特地改善了学习和记忆的脑路径,突出了它们的协同效应.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 饮食在一生中显著影响微生物群-肠-大脑轴.
- 牛奶的生物活性成分和益生菌支持肠道健康和认知功能.
研究的目的:
- 评估牛奶生物活性成分和益生菌在抵消早期微生物群枯竭效应方面的有效性.
- 研究它们对小鼠行为和大脑功能的影响.
主要方法:
- 小鼠在生命早期经历了微生物群的消耗,使用的是宽谱抗生素.
- 补充人乳寡糖化物 (HMO),银寡糖化物/果寡糖化物 (GOS/FOS) 或其组合.
- 进行了行为测试 (社会识别) 和对大脑区域 (杏仁体,前额叶皮层) 的转录组分析.
主要成果:
- 微生物群枯竭影响了幼年小鼠的社会认可.
- 补充HMO,GOS/FOS或它们的组合可以扭转这些行为缺陷.
- 联合补充剂独特调节了中枢神经系统的发育,学习和大脑中的记忆路径.
结论:
- 益生菌和牛奶生物活性成分有效地逆转与微生物群枯竭相关的行为缺陷.
- 联合补充剂为认知功能提供了独特的好处,包括学习和记忆.
- 这些饮食成分在减轻肠道失调对大脑健康的负面影响方面发挥着至关重要的作用.
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