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益生菌增强的氨酸减轻了小鼠中西斯普拉丁诱导的毒性
Kangxin Li1,2,3, Hui Yuan1,2, Jieyan Wang4
1Department of Endocrinology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, China.
iScience
|March 11, 2026
概括
基努伦酸 (KYNA) 通过减少炎症,亡和氧化应激来防止西斯的毒性. 益生菌补充剂可以增强内源性KYNA,提供类似的脏保护.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 西斯普拉丁化疗导致剂量依赖性毒性,限制了其临床使用.
- 氨酸 (KYNA) 是托的代谢物,具有潜在的保护性质.
研究的目的:
- 调查KYNA对西斯普拉丁诱导的损伤的脏保护作用.
- 阐明KYNA行动的基础多式联运机制.
- 探索益生菌补充剂在增强内源KYNA对脏保护方面的潜力.
主要方法:
- 给用西斯丁治疗的小鼠,通过腹腔内注射不同剂量的KYNA (100,250,500毫克/公斤).
- 评估了炎症标志物 (NF-κB p65通路,MAPKs),亡 (Bcl-2家族,caspase-3) 和抗氧化防御 (Nrf2通路).
- 研究了益生菌补充剂对内源KYNA水平和保护的影响.
主要成果:
- 剂量依赖的减弱的西斯普拉丁诱导的毒性.
- KYNA抑制了促炎性细胞因子,减少了细胞亡,并增强了抗氧化剂防御.
- 益生菌补充剂增加了内源KYNA的产生,提供了与高剂量KYNA单疗法相比的脏保护.
结论:
- KYNA 呈现出针对西斯甲毒性的多模式机制.
- 通过益生菌介导的代谢调节来增强内源性KYNA是一种可行的保护策略.
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