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在2型糖尿病和糖尿病病患者中增加尿液细胞外囊和减少NEDD4L的表达

Nikhil Thyagarajan¹, Richard Le Leu^1,2, Sharad Kumar^2,3,4

¹Central Northern Adelaide Renal and Transplantation Service (CNARTS), Central Adelaide Local Health Network, Royal Adelaide Hospital, Adelaide, South Australia, Australia, rah.sa.gov.au.

Journal of diabetes research

|March 11, 2026

概括

糖尿病脏病 (DN) 患者表现出尿液细胞外囊泡 (EVs) 的增加,其NEDD4L蛋白质较低. 在EVs中的这一发现反映了脏活检结果,表明尿路EVs是DN的潜在生物标志物.

科学领域:

腎臟病學 (nephrology) 是一種醫學.
生物化学生物化学
分子生物学分子生物学

背景情况:

糖尿病病 (DN) 是慢性病的主要原因,通常是晚期诊断出来的.
目前的诊断方法依赖于白蛋白尿或减少的膜过率.
细胞外囊泡 (EVs) 正在成为DN的有希望的生物标志物,反映出病理变化.

研究的目的:

在2型糖尿病患者 (T2DM) 的活检中分析NEDD4L表达.
与对照组相比,研究DN患者的尿液EV释放和NEDD4L表达.
为了确定尿液EV NEDD4L水平是否与脏活检结果相关.

主要方法:

分析了DN和对照对象T2DM患者的脏活检.
从患有DN的患者和没有糖尿病的对照人群收集尿液样本.
从尿液中分离出细胞外囊泡 (EVs),并在活检和EVs中量化NEDD4L蛋白表达.

主要成果:

与对照组相比,患有DN的患者在尿道异质EV的度较高.
在DN患者的尿路EV中,NEDD4L蛋白质表达显著降低.
尿路EV中降低的NEDD4L水平反映了脏活检样本中的发现.

结论:

患有DN的T2DM患者的尿液EV显示度增加和减少NEDD4L蛋白.
尿路EV可以作为T2DM相关DN的潜在生物标志物.
尿路EV中较低的NEDD4L水平可能表明DN相关的管道损伤的严重程度.

关键词:

糖尿病性脏病糖尿病脏病细胞外囊泡中的细胞外囊泡.脏活组织检查蛋白质表达蛋白质表达管道损伤的伤害是因为管道损伤.尿液尿液尿液

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