通过生物材料提供活药物
Tetsuhiro Harimoto1,2, Wei-Hung Jung1,2, David Mooney1,2
1John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.
概括
活体药物,用于治疗的工程细胞,需要先进的输送策略. 本综述探讨了这些变革性疗法的有效体内传递的挑战和生物材料解决方案.
科学领域:
- 生物医学工程 生物医学工程
- 细胞治疗学 细胞治疗学
- 药物输送系统 药物输送系统
背景情况:
- 活药物,包括工程细胞,真菌,细菌和病毒,对医学具有变革潜力.
- 目前活体药物的临床进展受到缺乏有效的体内输送策略的阻碍.
- 与传统疗法不同,活药需要管理生命力,复制,新陈代谢和免疫性.
研究的目的:
- 审查和分析现有的活药物输送策略.
- 确定与提供活药物相关的关键挑战.
- 探索生物材料策略的适应,从传统的药物输送到活体药物.
主要方法:
- 对临床采用的生物材料药物输送策略的文献综述.
- 分析活体药物输送所面临的具体挑战.
- 对细胞,真菌,细菌和病毒疗法的生物材料应用的探索.
主要成果:
- 活药物存在独特的输送障碍,包括维持细胞活力和控制生物功能.
- 常规药物使用的生物材料策略可以适应活体药物输送.
- 取得了显著的进展,但控制分娩和免疫性仍然存在挑战.
结论:
- 先进的输送系统对于活药物的临床转化至关重要.
- 定制生物材料为克服活体药物交付挑战提供了一个有希望的途径.
- 未来的研究应该专注于下一代的传递系统,以充分发挥活体治疗的潜力.
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